Fulgard

Generic composition: Fusidic acid

General Introduction

Fulgard is fusidic acid, antibiotic belonging to fusidane. It is derived from Fusidium coccineum. It has steroid like structure but does not possess steroidal activity. It has bactericidal activity against Staphylococcus, Streptococcus, and Corynebacterium. It inhibits bacterial replication.

Therapeutic category

• Topical Anti-bacterial

Dosage forms available

• FULGARD cream 15g

Mechanism of Action

Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.

Pharmacokinetics

Fusidic acid is highly protein bound and has good penetration to a number of tissues. Topical application has poor penetration through skin. It is excreted mainly in the bile with little excreted in the urine. Half-life in adult is approximately 5-6 hours,

Uses

• Soft tissue infections
• Infected dermatitis, folliculitis, furunculosis
• Angular cheilitis
• Abscesses and infected traumatic wounds

Dose

• Uncovered lesions: apply gently three or four times daily.
• Covered lesions: less frequent applications may be adequate.

Side effects

Cardiac glycosides

Contraindications

It is contraindicated in patients with known hypersensitivity to fusidic acid or to any of the excipients.