Mogyl Forte Tablet
Generic composition: Tinidazole 300mg and Diloxanide Fuorate 500mg
General Introduction
Mogyl forte contains Tinidazole and Diloxanide Furoate as an active ingredients and is an antiprotozoal and antiamoebic respectively.
Therapeutic category
- Anti-protozoal
Dosage forms available
- MOGYL Forte Tablets
Mechanism of action
Tinidazole: is anaerobicidal, amoebicidal. It inhibits bacterial nucleic acid formation.
Diloxanide furoate: Luminal amoebicide. It destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amoebiasis.
Pharmacokinetics
Tinidazole: Rapidly and completely absorbed, 12% plasma protein bound, undergoes hepatic metabolism by oxidation, hydroxylation and conjugation, crosses placental barrier and secreted in milk, excreted by liver and kidneys, plasma half life is 12 to 14 hours
Diloxanide furoate: slowly absorbed from GI tract,hydrolyzed to fuoric acid and diloxanide and metabolized by following glucoronidation, eliminated by renal route(90% as glucoronide metabolite) and 10% in feces, half life is 3 hours
Uses
- Amoebiasis and Giardiasis
- Prevention and treatment of anaerobic infection
Dose
- One tablet thrice daily for five days. Extended treatment for ten days in refractory cases
Side effects
Seizures, headache, dizziness, peripheral neuropathy, unpleasant metallic taste, furred tongue, GI disturbances
Contraindications
- first trimester pregnancy
- Lactation
- Hypersensitivity
- Active CNS disease, serious neurological disease and seizure
- Severe hepatic failure
Precautions
- The drug should be used with special precaution in renal and hepatic impairment. Alcoholic beverages should be avoided during the course.
Drug Interactions
- Acute psychoses with disulfiram
- Additive or synergistic effect with other antimicrobials
- Disulfiram like reaction with alcohol
- Enhances action of coumarin anticoagulants
- Blood levels increased by cimetidine
- Effect reduced by phenobarbitone
