Sovidone Gargle

Generic composition: Povidone Iodine

General Introduction

Povidone-iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine.

Therapeutic category

• Microbicidal

Dosage forms available

• SOVIDONE Gargle 1% in 50ml and 100ml

Pharmacodynamics

Povidone iodine is a kind of iodine disinfectant which directly causes in vivo protein denaturation, precipitation of bacteria, and further resulting in the death of pathogenic microorganisms. Therefore, it is effective in disinfection and sterilization.

It can kill viruses, bacteria, spores, fungi, and protozoa with low toxicity to human. Povidone-iodine aqueous solution has strong pharmacological activity against Staphylococcus aureus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, syphilis, hepatitis B virus, HIV, and Trichomonas vaginalis.

Mechanism of action

Povidone-iodine is called iodophore which means povidone acts as a carrier of iodine. Iodine is considered as the active moiety that mediates microbicidal actions. When released from the complex, free iodine penetrates the cell wall of microorganisms quickly, and the lethal effects are believed to result from disruption of protein and nucleic acid structure and synthesis. While the full mechanism of action is not fully elucidated, iodine is thought to inhibit vital bacterial cellular mechanisms and structures, and oxidizes nucleotides fatty or amino acids in bacterial cell membranes. Additionally, free iodine disrupts the function of the cytosolic enzymes involved in the respiratory chain, causing them to become denatured and deactivated.

 Uses

Treatment of acute infections of the lining of the mouth and throat, for example, inflammation of the gums (gingivitis) and mouth ulcers. For cleansing the mouth (oral hygiene) before, during and after dental and mouth surgery.

How to use

• Dilute with an equal amount of warm water if taste is an issue. Swish part of the solution briefly in the mouth and spit it out. Tilt your head backwards and garglefor a total of 30 seconds via swirling the liquid at the throat.

Contraindications

• Allergic to povidone-iodine or any of the other ingredients of this medicine.