Trisone
TRISONE
Generic composition: Mometasone Furoate
General Introduction
Mometasone furoate Cream, 0.1% contains mometasone furoate for topical use. Mometasone furoate is a synthetic corticosteroid with anti-inflammatory activity.
Mometasone Cream is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 2 years of age or older.
Therapeutic category
- Corticosteroids
Dosage forms available
- TRISONE 0.1% Cream
Mechanism of action
Like other topical corticosteroids, mometasone furoate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pharmacokinetics
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Studies in humans indicate that approximately 0.4% of the applied dose enters the circulation after 8 hours of contact on normal skin without occlusion. Inflammation and/or other disease processes in the skin may increase percutaneous absorption.
Uses
- Atopic and Contact Dermatitis
- Psoriasis
- Lichen Planus
Dosage
- Apply to the affected area once a day twice a day as directed by the doctor.
Side effects
- Skin rash, itching, redness, dryness, burning, tingling, thinning or softening of skin,
Precautions
- Pregnancy category: C
- Topical corticosteroids may increase the risk of posterior sub capsular cataracts and glaucoma.
Contraindications
- Hypersensitivity to any ingredients of Mometasone.
