LUCICAINE

Generic composition: Magaldrate 800mg, Simethicone 100mg and Oxetacaine 20mg/10ml

General Introduction

Lucicaine is an antacid that has triple benefits. It provides faster action. It neutralizes the excess acid in the stomach, prevents flatulence as well as makes insensate to pain.

Therapeutic category

• Anesthetic Antacid

Dosage form available

• LUCICAINE suspension in 170ml

Base and Flavour

• In a Peppermint flavoured sorbitol base

Mechanism of Action

Magaldrate: It is a hydrated complex of hydroxy magnesium aluminates which initially reacts with the gastric acid and releases Aluminum Hydroxide and Magnesium Hydroxide.  This will neutralize the excess acid in stomach, increase pH of stomach.

Simethicone: It acts by decreasing the surface tension of gas bubbles, thus facilitating their coalescence and expulsion as flatus or belching also preventing formation and accumulation of mucus-enclosed pockets of gas in digestive tract.

Oxetacaine: It is a local anesthetic which provides faster relief from pain due to ulcers or acidic injury in the stomach. Oxetacaine exerts a local anesthetic effect on the gastric mucosa.

Indications

• Dyspepsia
• Esophageal reflux, GERD
• Epigastric pain
• Symptomatic relief of Hyperacidity
• Heartburn
• Peptic ulcer
• IBS (Irritable bowel syndrome)
• Flatulence, abdominal distention, blotting, etc

Dose

For Adults, elderly and children over 12 years of age: 5-20ml three times daily 20 minutes to one hour after meals, and at bedtime, or as required. Not recommended for children below 12 years of age.

Side effects

Chalky taste, Diarrhea, Constipation, Allergic reaction

Precautions

• Avoid drinking anything immediately after taking this medicine as that can reduce its effectiveness.
• Do not take antacid medicines half an hour before or after taking this medicine.

Contraindications

• Hypersensitivity with use of aluminum or magnesium containing antacids

Advantages

• Oxetacaine containing antacids are being recommended as complementary to PPIs in GERD and related disease
• The local anesthetic agent helps relieve the pain caused due to hyperacidity and aluminum and magnesium hydroxide
• Good alternative for quick symptomatic relief
• The therapeutic spectrum of Anesthetic antacid will increase manifold, if in addition with Anti-flatulent Simethicone
• Some investigations has reported that Oxetacaine containing antacid produces persistent increase in gastric pH to 3.5 or above
• The anesthetic component Oxetacaine remains non-ionized at hyperacidic condition and produces a prolonged anesthetic effect (numbing effect) on the walls of the stomach, thereby bordening the therapeutic spectrum of antacids besides the normal process of neutralizing acid

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