Cefanol
Generic composition: Cefpodoxime Proxetil
General description
Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria
Therapeutic category
- Anti-bacterial (3rd generation Cephalosporin)
Dosage forms available
- CEFANOL 100mg Tablets
- CEFANOL 200mg Tablets
- CEFANOL Dry Syrup 50mg/5ml
Mechanism of action
- The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls.
Pharmacokinetics
- Absorption: absorbed from GI tract, bioavailability approximately 50%, protein binding is 22 to 33% in serum and from 21 to 29% in plasma.
- Metabolism: metabolized in liver
- Elimination: approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.
- Half-life: 09 to 2.84 hours
Uses
- ENT Infections
- Bronchitis
- UTI
- Pneumonia
- Skin and soft tissue infection
- Acute, uncomplicated urethral and cervical gonorrhea
- Surgical Infections
- Typhoid fever
Dose
- Adult: 100 mg two times a day q12 hourly for Pharyngitis, Tonsillitis, UTI, 200mg two times a day q12 hourly for Pneumonia, ENT infections, Bronchitis,
- Pediatric: 10ml two times a day 12 hourly
Side effects
Diarrhea, Nausea, headache, abdominal pain, vomiting, skin rash, dyspepsia,
Contraindication
Cefpodoxime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Drug Interactions
- Antacids (decreases the extent of absorption of cefanol
- Renal excretion of cefpodoxime was inhibited by probenecid
Precautions
Dose reduction in case of renal insufficiency. Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics.
