Cesone
CESONE
Generic composition: Fluticasone Propionate
General Introduction
Fluticasone is a synthetic fluorinated corticosteroid, for topical dermatologic use. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents.
Therapeutic category
- Corticosteroids
Dosage forms available
- CESONE 0.05% w/w cream
Mechanism of action
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Fluticasone propionate is lipophilic and has a strong affinity for the glucocorticoid receptor. It has weak affinity for the progesterone receptor, and virtually no affinity for the mineralocorticoid, estrogen, or androgen receptors.
Uses
- Atopic dermatitis
- Contact dermatitis
- Poison Ivy
- Seborrhoeic dermatitis
- Psoriasis
Dose
- Apply the cream to the affected area once or twice daily and rub gently or as directed by the dermatologists.
Precautions
For external use only.
Side effects
Burning, pruritus, stinging, skin irritation, dryness,
Contraindications
Patients with a history of hypersensitivity to any of the components of preparations.
