Rabizole

Generic composition: Rabiprazole sodium

General Introduction 

Rabezole is rabeprazole, proton pump inhibitor belonging to benzimidazole group same as pantoprazole. It causes fastest acid inhibition.

Therapeutic category

• Proton pump inhibitors

Dosage forms available

• RABEZOLE 20mg Tablets

Mechanism of action

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. 

Pharmacokinetics

Biovaailability is approximately 52%, plasma protein binding is 96.3%, undergoes hepatic metabolism, approximately 90% of the drug was eliminated in the urine, half-life is 1-2 hours

Uses

• GERD
• Esophagitis
• Eradication of H.pylori in combination with antibiotics
• Zollinger-Ellison Syndrome
• Peptic ulcer
• Heartburn
• Stress ulcer

Dose

• 20mg once daily before meal for up to 4 to 8 weeks 

Side effects

Bone fracture, hypomagnesimia, cynacobalamin deficiency, erythematosus, 

Contraindication

Patients with known hypersensitivity to rabeprazole

Precautions

Presence of gastric malignancy, acute interstinal nephritis,  erythmatosus, 

Drug Interactions 

With antiretroviral drugs, antirheumatic drug methotrexate, digoxin: increase its toxicity, anticoagulants.