Trisone T

TRISONE-T

Generic composition: Mometasone furoate 0.1% and Terbinafine 1% cream

General Introduction

Mometasone furoate cream is a synthetic corticosteroid with anti-inflammatory activity which is for topical use.

Terbinafine is a synthetic allylamine antifungal. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.

Therapeutic category

• Corticosteroids and combinations

Dosage form available

• TRISONE-T Cream

Mechanism of action

Terbinafine inhibits the enzyme squalene monooxygenase (also called squalene epoxidase), preventing the conversion of squalene to 2, 3-oxydosqualene, a step in the synthesis of ergosterol. This inhibition leads to decreased ergosterol, which would normally be incorporated into the cell wall, and accumulation of squalene, ultimately inhibits growth of fungi.

Mometasone furoate binds to a glucocorticoid receptor; receptors dimerize and bind to a DNA sequence known as the glucocorticoid response element which either increases expression of anti-inflammatory molecules or inhibits expression of pro-inflammatory molecules (such as interleukins 4 and 5). Mometasone furoate also reduces inflammation by blocking transcription factors such as activator-protein-1 and nuclear factor kappa B (NF-kappaB)

Dosage and administration

Apply a thin layer of the cream to the affected area as instructed by the doctor. Do not apply in larger or smaller quantities than recommended. Do not cover the application area with bandages or other coverings unless specifically instructed by the doctor.

Uses

• Used for treatment of topical fungal infections associated with redness, swelling, itching.

Side effects

• Application site reactions (burning, irritation, itching and redness), Skin peeling

Contraindications

• Known allergy to mometasone, terbinafine

Precautions

• Pregnancy and Lactating mothers
• Use with caution in patients with compromised immune systems.
• Photosensitivity (avoid exposure to sunlight)