THYLOBIN 1500
THYLOBIN 1500
Generic composition:
Each uncoated tablet contains: Mecobalamin JP 1500mcg
Drug Class: Anti-neuropathic Vitamin B12 Supplement
Description:
THYLOBIN 1500 is Mecobalamin 1500 microgram which is a naturally occuring and pure form of Vitamin B12. It regulates certain vital bodily functions like cell multipication, blood formation, and protein synthesis. It is used to Vitamin B12 deficiency in people with Megaloblastic anemia and Pernicious anemia.
Mechanism of action:
It works by functioning in the production of a compound called myelin, which covers and protect nerve fibres. Mecobalamin rejuvenates the damaged neuron. Without enough Mecobalamin, myelin sheath does not form properly due to which nerve fibres suffers and people experience irreversible nerve damage. An intrinsic factor made in the stomach, must be present in the intestinal tract to allow its proper absorption. People lacking this factor show Vitamin B12 defeiciencies such as Pernicious anemia.
Mecobalamin acts as coenzyme in the synthesis of methionine from homocysteine for various metabolic functions that are essential in cell replication and haematopoiesis. It also promotes nucleic acid and protein synthesis in nerve cells, production of all epithelial cells and maintenance of myelin throughout the nervous system. It causes increased myelination via promotion of lecithin synthesis, increase in nerve fibre excitability, and promotion of maturation and division of erythroblasts.
Pharmacokinetics
Mecobalamin binds with an intrinsic factor and form a complex which is absorbed in distal ileum. Mecobalamin adminstered orally is actively absorbed form the Gastrointestinal tract. Peak plasma concentration is reached in 3 hours as per oral dose. The half life of Mecobalamin is 6 days. It is extensively bound to Transcobalamin, disturbed to every cell of the body. It crosses placenta and enters breast milk. Excreation is occurred via urine.
Indication
- Peripheral neuropathy
- Diabetic neuropathy
- Neuropathic pain
- Vitamin B12 deficiency
- Megaloblastic anemia
- Pernicious anemia
- Homocysteinemia
Dose
The recommended dose is 1500mcg once daily in the morning. May be taken with food or without food or as directed by the physician.
Side effects
Nausea, vomiting, diarrhea, headache, abdominal pain, skin rash, anorexia
Drug interaction
- Decreased absorption with amino salicyclic acid, Chloramphenicol, Colchicine, H2 Blockers, Neomycin, PPIs
- Decreased serum concentration with oral contraceptives
- Impaired therapeutic response with large and continuous doses of folic acid
- Reduced absorption with alcohol intake
Precautions
Pregnancy and Lactation
Pregnancy Category: ‘C’
Contraindication
Hypersensitivity to Mecobalamin and other derivatives of Vitamin B12.
Advantages
- Natural form and most active form of Vitamin B12
- Acts as neuroprotectives and promotes myelination in neurons
- Significantly effective in peripheral neuropathy in both diabetic and non diabetic patients
