Nebalin

Nebalin

Pregabalin 50mg / 75mg / 150mg Capsules

Generic composition: Pregabalin

General Introduction

Nebalin is pregabalin, synthetic molecule with a favorable pharmacokinetic profile compared with gabapentin. It falls in the therapeutic category of anticonvulsant and non-opoid analgesics. It is used in the treatment for neuropathic pain.

Therapeutic category

• Anti-neuropathic drugs

Dosage forms available

• NEBALIN 50mg capsules
• NEBALIN 75mg capsules
• NEBALIN 150mg capsules

Mechanism of action

Pregabalin binds to calcium channel, resulting in reduced depolarization-induced calcium influx at nerve terminals with a consequential reduction in the release of excitatory neurotransmitters.

Pharmacokinetics

Pregabalin is rapidly absorbed, peak blood concentrations within 1 hour; average bioavailability exceeds 90%, half-life 5-7 hour. Pregabalin does not undergo hepatic metabolism and is not bound to plasma proteins. It is renally excreted, and 98% of the absorbed dose is excreted unchanged in the urine.

Uses

• Neuropathic pain (Diabetic neuropathic pain, fibromyalgia and Post herpetic neuralgia)
• Chronic pain
• Complex regional pain syndrome
• Epilepsy: as adjunctive therapy in adults with partial seizures with or without secondary generalization.
• Generalized Anxiety Disorder: treatment of Generalized Anxiety Disorder (GAD) in adults

Dose

150 mg per day in two or three divided dose, increased to 300mg in 3-7 days interval, maximum dose 600mg per day.

*Dose reduction in renal impairment

Side-effects

Dizziness, somnolence, ataxia, peripheral edema, weight gain, visual disturbances

Precautions

• Gradual withdrawal recommended
• Pregnancy category C: use with caution in pregnancy and lactation
• Use with caution in patients with history of angioedema
• Cardiovascular disease

Contraindications

• Hypersensitivity to Pregabalin or any of its components