MERYL BM
Generic composition: Terbutaline + Bromhexine
General introduction:
Terbutaline + Bromhexine is the combination of Bronchodilator and Mucolytic agent, hence the brand name MERYL BM.
Therapeutic category
- Bronchodilator and mucolytic agent
Dosage form available
- Each 5ml contains Terbutaline sulphate IP 2.5mg and Bromhexine HCl IP 8mg
Mechanism of action:
Terbutaline is a beta-adrenogernic agonist with preferential effects exerting bronchodilating and smooth muscle relaxation effects. Its pharmacologic mechanism is due to the stimulation of adenyl cyclase resulting in increased intracellular level of cyclic AMP. Elevated cAMP triggers relaxation of bronchial smooth muscle and inhibition of release of inflammatory mediators.
Bromhexine is a mucolytic that enhances mucus transport by increasing the amount of thin, watery, bronchial secreation and thereby decreasing viscosity. It increases cilia activity, resulting in enhanced mucociliar clearance, and has a secretolytic and scretomotor effect in the bronchial tract, which aids expectoration and eases cough.
Pharmacokinetics:
Terbutaline
Absorption: Tmax- 0.5h-1.5h, Bioavailability- 14-15%
Distribution: distributed to body tissues and is not highly bound to plasma protein
Metabolism: Metabolite: Sulfate conjugate
Excreation: Fecal (less than 1%), Renal (30-50%), half life- 3.4hr
Bromhexine
Absorption: absorbed from GIT
Distribution: distributed to body tissues and highly bound to plasma proteins
Metabolism: Metabolite: Sulfate conjugate
Excreation: 85-90% of dose is excreted in urine, half life: upto 12 hours
Crosses Blood brain barrier and small amounts cross the placenta
Indication:
- Bronchitis
- Bronchial asthma
- COPD
- Emphysema
- Bronchospasm
Dose: 5-10ml 3-4 times a day
Or As directed by physician.
Adverse effect: Nausea, Indigestion, Bloating, Diarrhea, Dizziness, Headache, Tremor, Sweating, Skin rash, Increased heart rate, Palpitations
Contraindication:
- Hypersensitivity to Bromhexine or any symphathomimetic amines or any component of terbutaline sulfate products.
Preacautions:
- Stop taking Terbutaline + Bromhexine and inform your doctor if your cough persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache.
Pregnancy category: C (Terbutaline), A (Bromhexine)
Advantage:
- Terbutaline is a bronchodilator which relaxes muscles in your airways and widens the airways.
- Bromhexine is a mucolytic which thins and loosens mucus (phlegm), making it easier to cough out. Together, they make breathing easier.
