Mycol

Generic composition: Clotrimazole

General Introduction

Clotrimazole is an imidazole group of anti-fungal agent. Topical application of an antifungal may reduce the risk of transmission.

Therapeutic category

• Anti-fungal (Topical)

Dosage forms available

• MYCOL 1% Cream

Mechanism of action

• Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes.
• If ergosterol synthesis is inhibited, the cell is no longer able to function, as ergosterol directly promotes the growth of fungal cells.

Pharmacokinetics

Clotrimazole is 98% protein bound, undergoes hepatic metabolism and eliminiated via hepatic route.

Uses

• Tinea Infections
• Candidiasis

Dosage

• Apply a thin layer over affected area two to three times a day or as directed by dermatologists.

Side effects

• Nausea, vomiting, unpleasant mouth sensations and pruritus

 Precautions

• Pregnancy category C
• Hepatic Impairment
• For external use only

Contraindications

• Contraindicated in patients who are hypersensitive to any of its components.